Emi1 Proteolysis
نویسندگان
چکیده
منابع مشابه
Emi1 ensures timely mitosis
Emi1 ensures timely mitosis T alk about a career change. Di Fiore and Pines report on page 425 that a protein long thought to inhibit mi-totic progression actually promotes mitosis and prevents cells from making too many copies of their DNA. The cell cycle is driven by destruction. To advance to the next stage, a cell demolishes the road blocks that keep progress in check. Flagging these obstac...
متن کاملSelective effects of Emi1 depletion in cancer
Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan, Research Center for Charged Particle Therapy and International Open Laboratory Particle Therapy Molecular Target Research Unit, National Institute of Radiological Sciences, Chiba 263-8555, Japan, Center of Oral Clinical Examination, Hiroshima Unive...
متن کاملEmi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C
Ubiquitin-mediated proteolysis is critical for the alternation between DNA replication and mitosis and for the key regulatory events in mitosis. The anaphase-promoting complex/cyclosome (APC/C) is a conserved ubiquitin ligase that has a fundamental role in regulating mitosis and the cell cycle in all eukaryotes. In vertebrate cells, early mitotic inhibitor 1 (Emi1) has been proposed as an impor...
متن کاملDNA damage triggers p21WAF1-dependent Emi1 down-regulation that maintains G2 arrest.
Several regulatory proteins control cell cycle progression. These include Emi1, an anaphase-promoting complex (APC) inhibitor whose destruction controls progression through mitosis to G1, and p21(WAF1), a cyclin-dependent kinase (CDK) inhibitor activated by DNA damage. We have analyzed the role of p21(WAF1) in G2-M phase checkpoint control and in prevention of polyploidy after DNA damage. After...
متن کاملProteolysis by Lactobacillus casei
A study of the proteinase activity of Lactobacillus casei grown in milk and of cell-free extract of L. cawi has been reported on in a previous paper (Brandsaeter and Nelson, 1956). Whereas the proteinases of L. casei have been studied to some extent earlier, very little has been done to characterize the peptidases of this organism. Other lactobacilli hydrolyze some peptides (Christophersen and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Cell
سال: 2003
ISSN: 1097-2765
DOI: 10.1016/s1097-2765(03)00233-8